Spicy Southern Cheesy Chicken Spaghetti Casserole Recipe

If you’re on the hunt for a comforting casserole that packs a flavorful punch, you’ve just found your new go-to: Spicy Southern Cheesy Chicken Spaghetti Casserole. This dish is a delightful marriage of tender chicken, gooey sharp cheddar, a medley of spices, and perfectly cooked spaghetti all baked into one irresistible, bubbly casserole. Whether you’re cooking for a weeknight family dinner or want to impress friends with a homestyle Southern classic, this recipe brings the warm, spicy, and cheesy goodness all in one dish.

Ingredients You’ll Need

The beauty of the Spicy Southern Cheesy Chicken Spaghetti Casserole lies in its straightforward ingredients, each playing a vital role in creating layers of flavor, texture, and color. From the creamy cheese to the fresh crunch of bell peppers, these ingredients come together harmoniously to make every bite memorable.

• Chicken breasts: Using boneless, skinless breasts ensures lean protein that cooks evenly and remains juicy.
• Spaghetti: This pasta acts as the hearty base, soaking up the rich sauce and spices beautifully.
• Sharp cheddar cheese: Adds a bold, creamy sharpness that melts into every corner of the casserole.
• Fresh bell peppers: Provide a sweet crunch and vibrant color that brighten the dish.
• Cream of chicken soup: Brings a velvety richness that binds everything together effortlessly.
• Paprika: Offers a subtle smoky warmth that complements the other spices perfectly.
• Cayenne pepper: Delivers a gentle kick of heat that livens up the casserole without overpowering it.
• Garlic powder: Infuses the dish with savory depth and aromatic flavor.
• Green onions: Freshly sliced, they add a mild oniony brightness for garnish and contrast.

How to Make Spicy Southern Cheesy Chicken Spaghetti Casserole

Step 1: Prep and Cook the Chicken

Start by preheating your oven to 350°F (175°C) and greasing a large casserole dish to prevent sticking. Then, cook your chicken breasts in a large pot over medium heat. Allow about 6 to 7 minutes per side until the chicken reaches a golden exterior and is cooked through. The chicken will be the foundation of your casserole, so getting that perfect juicy texture matters.

Step 2: Cook the Spaghetti

While your chicken cooks, bring a large pot of salted water to a boil. Toss in the spaghetti and cook until it’s al dente, usually about 8 to 10 minutes. Drain the pasta well — this ensures the casserole won’t be soggy and that the pasta holds up beautifully when baked.

Step 3: Combine Ingredients

In a large mixing bowl, shred the warm cooked chicken into bite-sized pieces. Then add the cooked spaghetti, cream of chicken soup, chopped bell peppers, paprika, cayenne pepper, garlic powder, and half of your shredded sharp cheddar cheese. Mix everything thoroughly until you have a thick, well-incorporated mixture that promises layers of flavor in every forkful.

Step 4: Assemble and Bake

Transfer the chicken and pasta mixture to the greased casserole dish, spreading it out evenly. Sprinkle the remaining cheddar cheese over the top to create a lovely golden crust as it bakes. Place your dish in the oven and bake for 25 to 30 minutes until the casserole is bubbly, the cheese is melted, and a beautiful golden brown is visible on top.

Step 5: Rest and Garnish

Once baked, let the casserole rest for about 5 minutes. This helps everything set up nicely for cleaner slices when serving. For a fresh finish, sprinkle sliced green onions over the top. They add a pop of color and subtle burst of flavor that brings this dish full circle.

How to Serve Spicy Southern Cheesy Chicken Spaghetti Casserole

Garnishes

Fresh green onions are a classic garnish here, their mild bite contrasting the creaminess of the casserole. You can also add a sprinkling of extra cheddar cheese before serving or a dash of smoked paprika for added color and aroma. If you want to turn up the heat, a few thinly sliced jalapeños won’t hurt!

Side Dishes

This casserole is hearty on its own, but pairing it with crisp, refreshing sides balances out the richness. A simple green salad with a zesty vinaigrette or some steamed broccoli provides a perfect textural contrast. For a Southern twist, serve with buttery cornbread or collard greens to complete the meal.

Creative Ways to Present

For dinner parties, serve the Spicy Southern Cheesy Chicken Spaghetti Casserole in individual ramekins for a personal touch. Layer some additional cheese on top and broil for a minute to get a quick bubbly crust. Alternatively, try topping with crushed tortilla chips for a fun crunchy surprise or mix in roasted corn for an extra burst of sweetness and texture.

Make Ahead and Storage

Storing Leftovers

Cool any leftovers to room temperature before transferring to an airtight container. Stored in the refrigerator, your Spicy Southern Cheesy Chicken Spaghetti Casserole will stay delicious for up to 3-4 days. Reheat gently to retain all that melty, cheesy goodness.

Freezing

This casserole freezes beautifully. To prepare for freezing, assemble the casserole but don’t bake it. Cover tightly with plastic wrap followed by foil, and freeze for up to 2 months. When ready to enjoy, thaw overnight in the refrigerator before baking as directed, adding a bit of extra time if baking from frozen.

Reheating

Reheat leftovers in the oven at 325°F (165°C), covered with foil to prevent drying out, until warmed through—usually about 20 minutes. You can also microwave individual servings, but watch carefully to avoid scorching the cheese or chicken. Adding a splash of milk or cream can help restore moisture.

FAQs

Can I use rotisserie chicken instead of cooking my own?

Absolutely! Using rotisserie chicken is a fantastic shortcut that saves time while still giving you tender, flavorful chicken for your casserole. Just shred it and proceed with the recipe as usual.

Is it possible to make this recipe without cream of chicken soup?

Yes, if you prefer to avoid canned soup, you can make a simple homemade sauce using butter, flour, chicken broth, and a splash of milk or cream. This allows you to control the ingredients while still getting that creamy texture.

How spicy is the Spicy Southern Cheesy Chicken Spaghetti Casserole?

The spice level here is moderate thanks to the cayenne pepper and paprika, giving the dish a warm, gentle heat without overwhelming the cheesy and savory flavors. You can always adjust the cayenne up or down to suit your taste.

Can I substitute gluten-free pasta in this dish?

Yes, gluten-free spaghetti works well in this casserole to accommodate dietary needs. Just be sure to cook it according to package instructions and keep an eye on the texture to prevent mushiness.

What type of cheddar cheese works best?

Sharp cheddar is recommended for its bold, tangy flavor that complements the spices perfectly. However, you can also use a mild cheddar if you prefer a subtler cheese presence, or even a mix of cheddar and Monterey Jack for extra meltiness.

Final Thoughts

There is something incredibly satisfying about diving into a warm, bubbly dish like Spicy Southern Cheesy Chicken Spaghetti Casserole. It’s comfort food elevated with a spicy kick and plenty of cheesy goodness. Whether you’re feeding a crowd or simply craving a hearty weeknight meal, this casserole promises to fill your kitchen with irresistible aromas and your table with smiles. Go ahead and try this recipe—you might just find a new family favorite to cherish for years!

Print